We propose a constructive and an iterated local search heuristic for minimizing the makespan in the non-permutation flow shop scheduling problem. Both heuristics are based on the observation that optimal non-permutation schedules often exhibit a permutation structure with a few local job inversions. In computational experiments we compare our heuristics to the best heuristics for finding non-permutation and permutation flow shop schedules, and evaluate the reduction in makespan and buffer size that can be achieved by non-permutation schedules.