Title
Malaria-specific antibody subclasses in immune individuals: A key source of information for vaccine design
Date Issued
01 January 2003
Access level
metadata only access
Resource Type
journal article
Author(s)
Center for Infectious Diseases
Publisher(s)
Elsevier Ltd
Abstract
Immunity against the blood stage of Plasmodium falciparum malaria is associated with protective-type antibodies of certain classes and subclasses. Field studies have demonstrated the differential regulation of various IgG subclasses depending on the dynamics of parasite transmission and on the immune status of the individuals tested. The intrinsic properties of each IgG subclass has a crucial role in protection, both because immunoglobulin levels are dependent on their production and clearance from blood and because antibodies are actively used for parasite clearance. In vitro models using B cells obtained from P. falciparum-immune adults have enabled study of the production of various antibody subclasses depending on the individual and on the antigens used. Ex vivo and in vitro observations from immune donors have helped to extend our understanding of the development and regulation of the antibody response and to design more effective vaccine strategies.
Start page
30
End page
35
Volume
24
Issue
1
Language
English
OCDE Knowledge area
Parasitología
Tecnología médica de laboratorio (análisis de muestras, tecnologías para el diagnóstico)
Inmunología
Scopus EID
2-s2.0-0037213611
PubMed ID
Source
Trends in Immunology
ISSN of the container
14714906
Sponsor(s)
We are grateful to present and former colleagues and collaborators at the Institut Pasteur in Paris, Dakar (Senegal) and Cayenne (French Guiana) for their respective contribution to the malaria studies. We also acknowledge present and former colleagues at the IRD (ex-ORSTOM) in Dakar, at the departments of Immunology and Parasitology at the University Medical School, University Cheikh Anta Diop in Dakar, and to the villagers of Dielmo and Ndiop (Senegal). This work has received constant support from the ‘Délégation au Réseau International des Instituts Pasteur et Instituts Associés (Institut Pasteur, France)’ and from the French Ministry for Cooperation and Cultural Development. We also thank E. Riley (London School of Hygiene and Tropical Medicine), D. C. Kaslow (NIAID, NIH, Bethesda) and O. Mercereau-Puijalon (Institut Pasteur, Paris) for long-term collaboration; E. Riley for sharing unpublished data; and G. Yap (Brown University, Providence) for helpful comments.
Sources of information:
Directorio de Producción Científica
Scopus