Title
Integrating, summarizing and visualizing GWAS-hits and human diversity with DANCE (Disease-ANCEstry networks)
Date Issued
15 April 2016
Access level
open access
Resource Type
journal article
Author(s)
Araújo G.S.
Lima L.H.C.
Schneider S.
Leal T.P.
Da Silva A.P.C.
Vaz De Melo P.O.S.
Scliar M.O.
Rodrigues M.R.
Universidad Federal de Minas Gerais
Publisher(s)
Oxford University Press
Abstract
Motivation: The 1000 Genomes Project (1KGP) and thousands of Genome-Wide Association Studies (GWAS) performed during the last years have generated an enormous amount of information that needs to be integrated to better understand the genetic architecture of complex diseases in different populations. This integration is important in areas such as genetics, epidemiology, anthropology, as well as admixture mapping design and GWAS-replications. Network-based approaches that explore the genetic bases of human diseases and traits have not yet incorporated information on genetic diversity among human populations. Results: We propose Disease-ANCEstry networks (DANCE), a graph-based web tool that allows to integrate and visualize information on human complex phenotypes and their GWAS-hits, as well as their risk allele frequencies in different populations. DANCE provides an interactive way to explore the human SNP-Disease Network and its projection, a Disease-Disease Network. With these functionalities, DANCE fills a gap in our ability to handle and understand the knowledge generated by GWAS and 1KGP. We provide a number of case studies that show how DANCE can be used to explore the relationships between human complex diseases, their genetic bases and variability in different human populations.
Start page
1247
End page
1249
Volume
32
Issue
8
Language
English
OCDE Knowledge area
Genética humana Epidemiología Antropología
Scopus EID
2-s2.0-84966570565
PubMed ID
Source
Bioinformatics
ISSN of the container
13674803
Sources of information: Directorio de Producción Científica Scopus