Landslides in the Andes are some of the highest natural threats to society with single events killing up to several thousand people. Landslide mapping and landslide research became a more widely spread discipline in geosciences in the Andean countries. However efforts today by far do not match the threat and both more investigations and more mapping activities are needed to support decision makers in land use planning. In this communication we discussed five key issues that we suggest to focus on in upcoming years: Impact of climatic change on landslides occurrence, landslides susceptibility and hazard maps, prediction of megalandslides, seismically triggered landslides, and temporal spatial distribution of mud and debris flows potential.