Title
Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum
Date Issued
17 December 2001
Access level
metadata only access
Resource Type
journal article
Author(s)
Seo E.K.
Kim N.C.
Mi Q.
Chai H.
Wall M.E.
Wani M.C.
Navarro H.A.
Burgess J.P.
Graham J.G.
Tan G.T.
Farnsworth N.R.
Pezzuto J.M.
Kinghorn A.D.
Abstract
A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.
Start page
1483
End page
1485
Volume
64
Issue
11
Language
English
OCDE Knowledge area
Oncología
Scopus EID
2-s2.0-0035199743
PubMed ID
Source
Journal of Natural Products
ISSN of the container
01633864
Sponsor(s)
National Cancer Institute - U19CA052956.
Sources of information:
Directorio de Producción Científica
Scopus