A hybrid large eddy simulation/filtered density function (LES/FDF) approach is used for studying chemically reacting flows with detailed chemistry. In particular, techniques utilised for ensuring a mass consistent coupling between LES and FDF are discussed. The purpose of these techniques is to maintain a correct spatial distribution of the computational particles representing specified amounts of fluid. A particular mass consistency technique due to Y.Z. Zhang and D.C. Haworth (A general mass consistency algorithm for hybrid particle/finite-volume PDF methods, J. Comput. Phys. 194 (2004), pp. 156–193) and their associated algorithms are implemented in a pressure-based computational fluid dynamics code suitable for the simulation of variable density flows, representative of those encountered in actual combustion applications. To assess the effectiveness of the referenced technique for enforcing LES/FDF mass consistency, two- and three-dimensional simulations of a temporal mixing layer using detailed and reduced chemistry mechanisms are carried out. The parametric analysis performed focuses on determining the influence on the level of mass consistency errors of parameters such as the initial number of particles per cell and the initial density ratio of the mixing layers. Particular emphasis is put on the computational burden that represents the use of such a mass consistency technique. The results show the suitability of this type of technique for ensuring the mass consistency required when utilising hybrid LES/FDF approaches. The level of agreement of the computed results with experimental data is also illustrated.