Title
Performance of a household tuberculosis exposure survey among children in a Latin American setting
Date Issued
01 November 2019
Access level
open access
Resource Type
journal article
Author(s)
Publisher(s)
International Union against Tubercul. and Lung Dis.
Abstract
O B J E C T I V E: To evaluate the performance of a survey that quantifies the intensity of household tuberculosis (TB) exposure among children. M E T H O D S: Children aged 0ā14 years in Lima, Peru, with ā„1 signs and/or symptoms of TB and a history of contact with an adult TB patient were included. The 10-question survey was administered to caregivers and addressed sleep proximity, frequency of exposure, and infectiousness of the contact. Infection status was determined using tuberculin skin tests (TSTs). The exposure scale was evaluated for association with TST positivity using mixed-effects regression analyses. R E S U LT S: The exposure score was significantly associated with TST positivity (age-adjusted odds ratio [aOR] 1.14, 95%CI 1.02ā1.28). We observed a stronger association with TST positivity in children aged ā¤5 years; (aOR 1.23, 95%CI 1.07ā1.41) and no association in children 6ā14 years of age (aOR 0.99, 95%CI 0.82ā1.20). C O N C L U S I O N: This survey was easy to use and modestly successful in predicting TST positivity in children aged ā¤5 years. It may be a useful resource for clinicians for diagnosing TB in children, and for national TB programs aiming to scale up preventive therapy initiatives.
Start page
1223
End page
1227
Volume
23
Issue
11
Language
English
OCDE Knowledge area
PediatrĆa
Enfermedades infecciosas
Sistema respiratorio
Subjects
Scopus EID
2-s2.0-85074959544
PubMed ID
Source
International Journal of Tuberculosis and Lung Disease
ISSN of the container
10273719
Sponsor(s)
The authors thank the National Institutes of Health (NIH/NIAID 5U19AI109755), Bethesda, MD, USA.
Sources of information:
Directorio de Producción CientĆfica
Scopus