Title
Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro
Date Issued
01 August 1997
Access level
metadata only access
Resource Type
journal article
Author(s)
Santa Maria A.
Lopez A.
Diaz M.
Galán De Mera A.
Vicente Orellana J.
Pozuelo J.
Publisher(s)
Elsevier B.V.
Abstract
Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.
Start page
183
End page
187
Volume
57
Issue
3
Language
English
OCDE Knowledge area
Farmacología, Farmacia
Toxicología
Subjects
Scopus EID
2-s2.0-0342617510
PubMed ID
Source
Journal of Ethnopharmacology
ISSN of the container
03788741
Sponsor(s)
The authors thank J. Muro and A. Polaina for technical assistance. We also wish to thank Linda Hamalainen for her linguistic advice. The project was supported by Instituto de Salud Carlos III and Universidad San Pablo (CEU) Proj 4/95.
Sources of information:
Directorio de Producción Científica
Scopus