It was proposed to evaluate hydrobiological information (phytoplankton, zooplankton, periphyton, benthic macroinvertebrates, and nekton) in two sampling points in the Lurín River at the height of the Antioquia district, Huarochirí Province, Lima. The methods of collection, identification, and analysis of biological communities were followed. Aquatic organisms were quantified. Taxonomic identification was carried out according to Prescott (1975). The results were analyzed with biological diversity indices using the PAST statistical program. The abundant species of phytoplankton in stations EP-01 and EP-02 were “Cocconeis placentula” and “Gomphonema subclavatum”, belonging to the Bacillariophyta family.Regarding zooplankton, in stations EP-01 and EP-02 in both seasonality it presented little biological diversity. In the Periphyton in both seasons and times, equitable abundance between species was evident. Macroinvertebrates (EP-01 and EP-02) during the dry and wet seasons present good ecological quality of water and regulate water quality. In conclusion, the biological composition of the water body and some cities' socioeconomic activity in Antioquia were evidenced.