Title
In vivo selection of plasmodium falciparum pfcrt and pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso
Date Issued
01 January 2015
Access level
open access
Resource Type
journal article
Author(s)
Baraka V.
Tinto H.
Valea I.
Fitzhenry R.
Mbonye M.K.
Van Overmeir C.
Rosanas-Urgell A.
Van Geertruyden J.P.
D'Alessro U.
Erhartd A.
Universidad de Amberes
Publisher(s)
American Society for Microbiology
Abstract
Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHAPPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.
Start page
734
End page
737
Volume
59
Issue
1
Language
English
OCDE Knowledge area
Genética, Herencia
Scopus EID
2-s2.0-84920115886
PubMed ID
Source
Antimicrobial Agents and Chemotherapy
ISSN of the container
00664804
Sources of information:
Directorio de Producción Científica
Scopus