Introduction and Objectives: Adjuvant therapy with vitamins C and E has been proposed to increase standard triple therapy’s Helicobacter pylori eradication rate. This study tested this hypothesis in a cohort of patients from the Peruvian Amazon. Material and Methods: We retrospectively evaluated a cohort of 50 patients at Tarapoto Hospital who were treated for H. pylori infections from July to December 2016. Of these, 25 were randomly selected to receive standard triple therapy of 1 g amoxicillin, 500mg clarithromycin and 20mg omeprazole twice a day for 14 days plus adjuvant vitamins C and E. The other 25 only received standard triple therapy. The effectiveness of both treatments was estimated and compared using a general linear regression model using the Poisson family of distributions and log link with H. pylori eradication confirmed by histopathology as the outcome of interest. Results: A comparison of the two groups found no significant differences in their baseline symptoms, histopathological diagnoses, ages (38 ± 11 years vs. 36 ± 10 years) or genders (65% male vs. 63% male). A comparison of the effectiveness both treatments found a non-significant increase in eradication rates of 9.5% (91% vs. 82%, incidence rate ratio = 1.11; 95% confidence interval: 0.92 to 1.36). Conclusions: Adjuvant therapy with vitamins C and E may help increase the effectiveness of standard triple therapy for H. pylori in patients in the Peruvian Amazon, although this hypothesis needs to be confirmed in a clinical trial.