The purpose of this study is to identify the factors that influence entrepreneurial intention in virtual university students enrolled at the Fundación Universitaria Católica del Norte (Medellin, Colombia) by applying the theory of planned behavior and the model of entrepreneurial event. The methodology is descriptive-quantitative. A factor analysis is applied on a survey of 461 university students enrolled in study programs that are 100% online. The results show that students' attitudes, current and perceived behavioral controls, and entrepreneurial behavior significantly influence student entrepreneurial intentions. Personal attitude is the most important factor. In conclusion, the present study makes a contribution to the subject of entrepreneurial intention that can serve as a basis for strengthening initiatives aimed at improving virtual-mode entrepreneurial education.