Title
Shear Wave Elastography in the Living, Perfused, Post-Delivery Placenta
Date Issued
01 June 2016
Access level
metadata only access
Resource Type
journal article
Author(s)
McAleavey S.
Parker K.
Wood R.
Stodgell C.
Katzman P.
Pressman E.
Miller R.
University of Rochester
Publisher(s)
Elsevier USA
Abstract
The placenta is the critical interface between the mother and the developing fetus and is essential for survival and growth. Despite the widespread use of ultrasound imaging and Doppler in obstetrics and gynecology and the recent growth of elastographic technologies, little is known about the biomechanical (elastic shear wave) properties of the placenta and the range of normal and pathologic parameters that are present. This study uses a well-developed protocol for perfusing whole placentas, post-delivery, to maintain tissue integrity and function for hours. In this model, the placenta is living, whole and maintained within normal physiologic parameters such as flow, arterial pressure and oxygen, throughout examination by ultrasound, Doppler and shear wave elastography. The preliminary results indicate that normal placental tissue on the fetal side has shear wave speeds on the order of 2 m/s, in a range similar to those of animal livers. Some abnormalities are found outside this range, and thus, elastographic measures of the placenta may provide useful assessments related to the state of the tissue.
Start page
1282
End page
1288
Volume
42
Issue
6
Language
English
OCDE Knowledge area
Obstetricia, Ginecología Biología del desarrollo
Scopus EID
2-s2.0-84962560990
PubMed ID
Source
Ultrasound in Medicine and Biology
ISSN of the container
03015629
DOI of the container
10.1016/j.ultrasmedbio.2016.01.009
Source funding
School of Medicine and Dentistry, University of Rochester
University of Rochester Hajim School of Engineering and Applied Sciences
Sponsor(s)
The authors are grateful to Jonathan Langdon for implementation of the SWS-SWEI, to Dr. Loralei Thornburg and Dr. Tulin Ozcan for their advice and guidance and to Siemens Corporation for their technical support. This work was supported by the University of Rochester School of Medicine and Dentistry and the University of Rochester Hajim School of Engineering and Applied Sciences .
Sources of information: Directorio de Producción Científica Scopus