Title
Antifilarial igg4 antibodies in children from filaria-endemic areas correlate with duration of infection and are dissociated from antifilarial ige antibodies
Date Issued
01 January 1994
Access level
metadata only access
Resource Type
journal article
Author(s)
National Institutes of Health
Abstract
To investigate the relationship of antifilarial IgG4 and IgE to the intensity of transmission and duration of filarial infections in endemic populations, antifilarial antibody levels in children residing in a village in Papua New Guinea where transmission of Wuchereria bancrofti was reduced by repeated insecticide spraying were compared with levels in residents of three nearby villages where no control measures had been used. Antifilarial IgG4 levels were significantly lower in children from the sprayed village than in children or adults in nonsprayed villages (P <.01) and correlated with age (P <.05) and intensity of microfilaremia (P <.01). In contrast, antifilarial IgE was elevated to similar levels in children and adults from both villages. Antifilarial IgG4 (and not IgE) levels in endemic populations appear to be directly related to the duration of infection or to the cumulative exposure to infective vectors. © 1994 by The University of Chicago.
Start page
1339
End page
1343
Volume
170
Issue
5
Language
English
Scopus EID
2-s2.0-0028130244
PubMed ID
Source
Journal of Infectious Diseases
ISSN of the container
00221899
Sponsor(s)
Received 17 February 1994; revised 5 July 1994. Presented in part: Infectious Diseases Society ofAmerica annual meeting, New Orleans. October 1993. Informed consent was obtained from patients or their parents or guardians, and human experimentation guidelines of the National Institutes of Health and Case Western Reserve University were followed. Grant support: World Health Organization/Tropical Diseases ResearchFilariasis Programme; National Institutes of Health (AI-15351). Reprints or correspondence: Dr. Siddhartha Mahanty, Laboratory of Parasitic Diseases, NIAID. Bldg. 4. Room 126, National Institutes of Health. Bethesda, MD 20892.
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