The Health-related quality of life corresponds to the perception that people have of their level of well-being, considering aspects of their lives and their impact on their state of health. The studies were initially carried out in a population that presented both acute and chronic pathologies and covered practically all areas of medical specialties; subsequently, the interest focused on studying health-related quality of life in the general population and then in the population of children and adolescents. That is why, in this research work, the evaluation of the adolescent to prevent future problems was raised; to carry out the evaluation, the questionnaire called KIDSCREEN 52 was used, which consists of 52 closed questions divided into 10 dimensions, providing an idea of how the adolescent feels. The following results were obtained: The Health-related quality of life in adolescents of an Educational Institution of Ventanilla, where 430 students representing 59.1% have high quality of life and 298 students representing 40.9% have medium quality of life; according to its dimensions, adolescents from the Educational Institution of Ventanilla, its most affected dimension was economic resources, with 64 students representing 8.8% having a low level. In the relationship with parents’ dimension, it appreciates that 3.4% of students do not have a good family atmosphere since they do not live with their parents, but with uncles and/or grandparents.