NASA Platform for Autonomous Systems (NPAS) is a disruptive software platform and processes being developed by the NASA Stennis Space Center (SSC) Autonomous Systems Laboratory (ASL). Autonomous operations are critical for the success, safety and crew survival of NASA deep space missions beyond low Earth orbit, including the Gateway, and for the future of cost-effective ground mission operations. NPAS represents the embodiment of an innovative paradigm for “thinking” autonomy in contrast to brute-force autonomy. NPAS uniquely addresses the requirements and integrates the primary functionalities for autonomous operations, in one platform that includes: (1) Integrated System Health Management (ISHM); (2) autonomy strategies, guided by system health and concepts of operations; (3) domain objects (system elements) and infrastructure to create complete application domain knowledge models (4) infrastructure to create, schedule, and execute mission plans; (5) infrastructure to develop user interfaces for comprehensive awareness; and (6) infrastructure to integrate distributed autonomous applications across networks. NPAS is a single platform that can be used to make any system operate with any desirable degree of autonomy, as well as provide comprehensive system awareness to operators and users.