In the H-scan analysis and display, visualization of different scattering sizes and types is enabled by a matched filter approach involving different orders of Gaussian weighted Hermite functions. An important question with respect to clinical applications involves the change in H-scan outputs with respect to small changes in scatterer sizes. The sensitivity of H-scan outputs is analyzed using the theory of backscatter from a compressible sphere. Experimental corroboration is established using mono dispersed spherical scatterers in phantoms. With a 6-MHz center frequency broadband transducer, it is possible to visualize changes in scattering size in the order of 10 to 15 μm in phantoms and also changes in ex vivo bovine liver tissue due to edema caused by hypotonic perfusion.