Weberbauera incisa Al-Shehbaz, P. Gonzáles & A. Cano (Brassicaceae), a new species from southern Peru, is described and illustrated. It differs from the closely related W. spathulifolia (A. Gray) O. E. Schulz by being completely glabrous and by having incised leaves, flattened and papery petioles of basal leaves, and torulose fruits.