Influence of surface modification of barium titanate nanoparticles of spherical shape with the average size of 200 nm in ferroelectric tetragonal crystal phase on the value of piezoelectric response by piezoelectric force microscopy has been studied. It has been found that the modification of the surface of nanoparticles with organic molecules for the increasing of biocompatibility leads to a decrease in the value of effective piezo response from 150 to 48–60 pm/V. At the same time, it is possible to switch polarization in the investigated samples. This allows to consider the mentioned nanocomposites to be promising materials for diagnostics and treatment of cancer tumors, as well as creation of new generation implants accelerating the osteogenesis process.