A summary is provided for the relevant issues that investigators must address when wishing to synthesize data via a meta‐analysis. The analogy is made to conducting a clinical trial and its components. Both design and statistical issues are discussed with the goal of assuring that the proper elements are included in the meta‐analysis. Further, global concerns are presented so that the researcher is aware of the clinical controversies faced when conducting a meta‐analysis. Finally a comparison is made of the advantages and disadvantages of a large‐scale clinical trial versus a meta‐analysis. Copyright © 1994 American College of Rheumatology