Students and teachers face problems in the teaching-learning processes of matrix algebra, due to the level of abstraction required, the difficulty of calculation and the way in which the contents are presented. Problem-based Learning (PBL) arises as a solution to this problem, as it contextualizes the contents in everyday life, allows students to actively build that knowledge and contributes to the development of skills. The proposal describes a didactic sequence based on PBL, which uses cooperative techniques and MATLAB, as instruments that facilitate the resolution of problems close to the student experience. The features of the Moodle platform are used to support the face-to-face educational process. The perception of students, in relation to the activity shows that 83% believe that it contributed to the understanding of the topics covered and 79% think that it allowed them to develop their creativity and capacity for expression.