Cameron lesions are becoming an increasingly important diagnosis in the evaluation of patients with iron deficiency anemia. We describe the demographic data, clinico-pathologic features and therapeutic outcome of a group of patients with Cameron lesions at a single private practice clinic in Lima, Peru. Twelve patients (9 men) were included in the report Median age at diagnosis was 71 years (range 49-91). Five patients had anemia and one of them had severe anemia. 91.7% of our patients presented with large hiatal| hernias. There were 5 patients with anemia and large hernias. Two patients tested positive for H. pylori. Two patients reported chronic NSAIDs use. Conclusions: Cameron lesions are not an uncommon cause of chronic gastrointestinal bleeding and should be kept in mind in the study of patients with iron deficiency anemia.