Title
Preclinical testing of three south American antivenoms against the venoms of five medically-important Peruvian snake venoms
Date Issued
01 July 2004
Access level
metadata only access
Resource Type
journal article
Abstract
World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru. © 2004 Elsevier Ltd. All rights reserved.
Start page
103
End page
106
Volume
44
Issue
1
Language
English
OCDE Knowledge area
Toxicología
Subjects
Scopus EID
2-s2.0-3042596850
PubMed ID
Source
Toxicon
ISSN of the container
00410101
Sponsor(s)
The authors gratefully acknowledge the financial support, advice and assistance of the British Council (Lima) without which it would not have been possible to carry out this study.
Sources of information:
Directorio de Producción Científica
Scopus