We present a case of an elderly female, without past medical history of alcohol, medication or hepatotoxic substances intake, with negative serology studies for viral hepatitis, who had evidence of chronic liver disease (Score B in the Child-Turcotte-Pugh scoring system). The patient presents mixed clinical, serologic, immunologic and histologic features of Autoimmune Hepatitis and Primary Biliary Cirrhosis. We postulate this is a variant or overlap syndrome.