Cystic fibrosis (CF) is a chronic lung disease with wide distribution worldwide. With the appearance of the Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), difficulties arise when evaluating, diagnosing, and treating patients with other conditions, including CF. We present the case of a patient with CF who had a definite serological diagnosis, a CT scan suggestive of SARS-CoV-2 infection/COVID-19, and a negative molecular test (RT-PCR), with rapid resolution of symptoms and early discharge. CF/SARS-CoV-2 comorbidity needs to be adequately studied and assessed in the context of the COVID-19 pandemic.