Title
Quantile regression for nonlinear mixed effects models: a likelihood based perspective
Date Issued
01 June 2020
Access level
metadata only access
Resource Type
journal article
Author(s)
Galarza C.E.
Louzada F.
Lachos V.H.
Pontificia Universidad Católica de Chile
Publisher(s)
Springer
Abstract
Longitudinal data are frequently analyzed using normal mixed effects models. Moreover, the traditional estimation methods are based on mean regression, which leads to non-robust parameter estimation under non-normal error distribution. However, at least in principle, quantile regression (QR) is more robust in the presence of outliers/influential observations and misspecification of the error distributions when compared to the conventional mean regression approach. In this context, this paper develops a likelihood-based approach for estimating QR models with correlated continuous longitudinal data using the asymmetric Laplace distribution. Our approach relies on the stochastic approximation of the EM algorithm (SAEM algorithm), obtaining maximum likelihood estimates of the fixed effects and variance components in the case of nonlinear mixed effects (NLME) models. We evaluate the finite sample performance of the SAEM algorithm and asymptotic properties of the ML estimates through simulation experiments. Moreover, two real life datasets are used to illustrate our proposed method using the qrNLMM package from R.
Start page
1281
End page
1307
Volume
61
Issue
3
Language
English
OCDE Knowledge area
Estadísticas, Probabilidad Matemáticas
Scopus EID
2-s2.0-85042424591
Source
Statistical Papers
ISSN of the container
09325026
Sponsor(s)
We thank the Editor and two anonymous referees whose constructive comments and suggestions led to an improved presentation of the paper. The research of C. Galarza was supported by Grant 2015/17110-9 from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP-Brazil). L. M. Castro acknowledges Grant Fondecyt 1170258 from the Chilean government. The research of F. Louzada was supported by Grant 305351/2013-3 from from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-Brazil) and by Grant 2013/07375-0 from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP-Brazil).
Sources of information: Directorio de Producción Científica Scopus