This paper analyzes the joint effects of in-phase and quadrature (I/Q) imbalance and power amplifier (PA) distortion for RF multiple input multiple output (MIMO) transmitters in the presence of crosstalk. This paper proposes candidate models for the digital predistortion of static I/Q imbalanced sources exciting a dynamic MIMO Volterra system. The proposed models are enhanced using a novel technique based on subsample resolution to account for dynamic I/Q imbalance distortions. Finally, the computational complexity of the proposed models is analyzed for implementation suitability in digital platforms. It is shown that the error spectrum for the proposed models in subsample resolution reaches the noise floor of the measurements. The proposed models achieve a normalized mean squared error of-50 dB and an adjacent channel power ratio of-57 dB for signal bandwidths upto 65 MHz and crosstalk levels ranging to-10 dB. These results demonstrate the effectiveness of the proposed techniques in the joint mitigation of I/Q imbalance and PA distortion with crosstalk for a typical 2 × 2 MIMO telecommunication setup.