Title
Micromotors as "motherships": A Concept for the Transport, Delivery, and Enzymatic Release of Molecular Cargo via Nanoparticles
Date Issued
13 August 2019
Access level
metadata only access
Resource Type
journal article
Author(s)
Kroupa T.
Hermanová S.
Novotný F.
Sofer Z.
Pumera M.
Universidad de Química y Tecnología de Praga
Publisher(s)
American Chemical Society
Abstract
Nano/micromotors based on biodegradable and biocompatible polymers represent a progressively developing group of self-propelled artificial devices capable of delivering biologically active compounds to target sites. The majority of these machines are micron sized, and biologically active compounds are simply attached to their surface. Micron-sized devices cannot enter cells, but they provide rapid velocity, which scales down with the size of the device; nanosized devices can enter cells, but their velocity is negligible. An advanced hierarchical design of the micro/nanodevices is an important tool in the development of functional biocompatible transport systems and their implementation in real in vivo applications. In this work, we demonstrate a "mothership" concept, whereby self-propelled microrobots transport smaller cargo-carrying nanorobots that are released by enzymatic degradation.
Start page
10618
End page
10624
Volume
35
Issue
32
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular Nano-materiales
Scopus EID
2-s2.0-85070701942
PubMed ID
Source
Langmuir
ISSN of the container
07437463
Sponsor(s)
This work was supported by the project Advanced Functional Nanorobots (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR) and from specific university research (MSMT No 21-SVV/2019).
Sources of information: Directorio de Producción Científica Scopus