The countries of the Region of the Americas Numerous have experienced many changes since the Declaration of Alma- Ata in 1978, such as globalization, new epidemiologic and demographic profiles, and the information and communication technology revolution. Nevertheless, the primary health care models in many countries of the region still endure numerous challenges, including the disarticulation of the levels of care and an inefficient management of information. It is urgent to implement a strong, flexible, and interoperable health information system that would allow the suitable access to precise, reliable, and consistent information about the health of the population. This article discusses the perspectives to develop a digital primary health care system.