Pedestrians in Peru are the victims of the greatest proportion of road traffic fatalities in the world. In 2009, pedestrians were involved in 27% of road traffic incidents in Peru. This is a significant public health problem in Peru and it has important economic effects as well. We review the evidence for some of the solutions and interventions implemented in other countries that may work well in Peru to confront this problem via preventing pedestrian-vehicle incidents. Most importantly, deploying interventions such as area-wide traffic calming through speed bumps, roundabouts, better lighting, one-way streets, detours, and blocking some roads has the strongest evidence for reducing injuries and fatalities in pedestrians. Other interventions related to education and enforcement may have a role as well in very specific contexts, but overall designing and modifying the built environment is the most important intervention.