Title
Atherogenic Dyslipidemia in Latin America: Prevalence, causes and treatment: Expert's position paper made by The Latin American Academy for the Study of Lipids (ALALIP) Endorsed by the Inter-American Society of Cardiology (IASC), the South American Society of Cardiology (SSC), the Pan-American College of Endothelium (PACE), and the International Atherosclerosis Society (IAS)
Date Issued
15 September 2017
Access level
metadata only access
Resource Type
journal article
Author(s)
Ponte-Negretti C.I.
Isea-Perez J.E.
Lorenzatti A.J.
Lopez-Jaramillo P.
Wyss-Q F.S.
Pintó X.
Lanas F.
Medina J.
Machado-H L.T.
Acevedo M.
Varleta P.
Carrera C.
Peñaherrera C.E.
Gómez-M J.R.
Lozada A.
Merchan-V A.
Piskorz D.
Morales E.
Paniagua M.
Villar-M R.A.
Cobos L.
Gómez-Alvares E.
Alonso R.
Colan J.
Chirinos J.
Lara J.
Ullauri V.
Arocha I.
Publisher(s)
Elsevier Ireland Ltd
Abstract
This is an executive summary made by a group of experts named Latin American Academy for the study of Lipids (ALALIP). In the current clinical guidelines, atherogenic dyslipidemia (AD) is a poorly recognized entity. Due to the frequent lipid alterations associated with AD in Latin America (LA), we organized a group of experts named (ALALIP) to generate a document in order to analyze their prevalence and to offer practical recommendations. Methodology: using the Delphi methodology, we conducted a comprehensive literature review with emphasis on those publications related to LA. Subsequently, we developed key questions for discussion. As a convention, those recommendations that had a 100% of acceptance were considered unanimous, those with >80% were consensual, and those with <80% were in disagreement. Results: a systematic analysis of national health surveys and regional cohort studies showed a consistently high prevalence of the lipid abnormalities that define AD: low levels of high-density lipoprotein cholesterol (HDL-C) range from 34.1% to 53.3% and elevated triglycerides (TG) range from 25.5% to 31.2%. These abnormalities could be related to high consumption of food with a high caloric density, cholesterol and trans fats, a sedentary lifestyle and perhaps epigenetic changes Conclusions lipid abnormalities that define AD have a high prevalence in LA. The interaction between an unfavorable lifestyle, inheritance and epigenetic changes is probably their cause. It is important to design a global study of risk factors in LA to know its true prevalence in the region, its consequences and to derive from its treatment strategies.
Start page
516
End page
522
Volume
243
Language
English
Scopus EID
2-s2.0-85019860912
PubMed ID
Source
International Journal of Cardiology
ISSN of the container
01675273
Sources of information:
Directorio de Producción Científica
Scopus