Probiotics are microorganism components that are beneficial to the health of a host; most probiotic microorganisms are lactic acid bacteria. Probiotics are dietary supplements appended to food that enhances human life and fights disease. It is a concept that has many faces used by known bacteria and goods that are biologically active. Probiotics are usable alternatives to antibiotics for livestock and may possibility be used as a substitute for antibiotics in animal farming, per the literature which has been accumulated to online databases, for example, PubMed, Scopus, Web of Science, Google Scholar, ScienceDirect, and MEDLINE. However, the research focused mainly on immunomodulation and dramatic reductions in gastrointestinal tract-attacking pathogens. Furthermore, historical safety cannot be bypassed with conventional strains of each novel probiotic and wild types of relevant antimicrobials that don’t belong to any strain. The description takes into account the relationship between probiotics and living beings for sustainable life.