The aim of this study is to determine the clinical efficacy of platelet rich plasma (PRP) for second degree burns. The time required for tissue reepithelization of lesions, down time associated with wound healing and patient satisfaction, are studied. We conduct a prospective, observational and long term study on 115 patients with second degree burns according to Converse-Smith classification. The lesions were of less than 48 hour evolution, located in different areas of the face and body. All patients received outpatient drip PRP, completing the treatment with the application of paraffin wax coated dressing and occlusive bandage. The study was carried out between March 2011 and August 2013. Lesions wit a better outcome and faster heal were those located on the face, followed by those on the abdomen and lastly those on the legs. In all cases reepithelization time was 30% less compared to patients with burns of similar size, deepness and location, treated without PRP. Patients were treated as outpatients when lesions permitted. When lesions were more extensive, patients were hospitalized. Hospital stay in these case was decreased an average of 18 days when compared to patients not treated with PRP. Reepitelizatión time, hospital stay and patient satisfaction with the results achieved, reached a statistical value of p<0,05. In conclusion, the use of PRP shortens recovery time for second degree burns, reducing hospital stay as well as obtaining a high patient satisfaction with results achieved.