Stress is one of the most recurrent problems in health professionals, but during the pandemic a high rate has been expected due to the high demand for COVID-19 infections, which has generated mental imbalance in health professionals and for this reason they cannot provide good care, so the research objective is to determine the Stress in Nursing Professionals who work in the First Line of Care against COVID-19 In North Lima. It is a study with quantitative - descriptive, non-experimental, and cross-sectional methodology, made up of a total of 255 study participants who responded to a survey of sociodemographic aspects and the Nursing Stress Scale. In their results, we observe that 55 (21.6%) of the nursing professionals present high stress, 139 (54.5%) medium stress and 61 (23.9%) low stress. In conclusion, it should be coordinated with professionals specialized in mental health to conduct an intervention program in the management of stress in the situation of the COVID-19 pandemic in nursing professionals.