This study presents applications of Bézier curves as design and analysis tools in two engineering study cases. In the first case, different types of metal–semiconductor self-assembled samples, made of silver nanowires and zinc oxide nanorods, were electrically and thermally characterized (Resistance & Temperature) according to the main merit figure for bolometric detectors. The Thermal Coefficient of Resistance (TCR) was used in order to assess their performance as bolometric materials. The representation of the graphical behavior was obtained using spline interpolation, applied for three samples of different concentration of Ag/ZnO, smoothing the obtained curve, results showed that higher ZnO concentrations will result in films with higher resistance and higher TCR, having the possibility to tune important parameters such as the TCR and film resistance by changing the ZnO concentration of the sample. In the second case, Bézier curves are controlled by means of genetic algorithms to obtain the maximum concentration or emission of electromagnetic radiation in a specific frequency range of the nanoantenna under study. In this way, Bézier curves have been presented as an optional tool for geometric manipulation assisted by computer in specialized engineering applications that could be useful in similar works.