Title
Deep clustering for metagenomics
Date Issued
01 January 2020
Access level
metadata only access
Resource Type
conference paper
Author(s)
EIA University
Publisher(s)
Springer Science and Business Media Deutschland GmbH
Abstract
Metagenomics is an area that is supported by modern next generation sequencing technology, which investigates microorganisms obtained directly from environmental samples, without the need to isolate them. This type of sequencing results in a large number of DNA fragments from different organisms. Thus, the challenge consists in identifying groups of DNA sequences that belong to the same organism. The use of supervised methods for solving this problem is limited, despite the fact that large databases of species sequences are available, by the small number of species that are known. Additionally, by the required computational processing time to analyse segments against species sequences. In order to overcome these problems, a binning process can be used for the reconstruction and identification of a set of metagenomic fragments. The binning process serves as a step of pre-processing to join fragments into groups of the same taxonomic levels. In this work, we propose the application of a clustering model, with a feature extraction process that uses an autoencoder neural network. For the clustering a k-means is used that begins with a k-value which is large enough to obtain very pure clusters. These are reduced through a process of combining various distance functions. The results show that the proposed method outperforms the k-means and other classical methods of feature extraction such as PCA, obtaining 90% of purity.
Start page
335
End page
347
Volume
12313 LNBI
Language
English
OCDE Knowledge area
Bioinformática
Ciencias de la computación
Subjects
Scopus EID
2-s2.0-85098267272
Source
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ISSN of the container
03029743
ISBN of the container
9783030630607
Conference
16th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2019
Sources of information:
Directorio de Producción Científica
Scopus