The Indonesian government has set a target to reduce between 26% and 41% (0.767 to 1.2095) Gt of CO2e by 2020 based on 2005 emissions. This study determined the potential for achieving this target using Kupang City as a case study. We introduced Kupang government needs and the current social-economic situation related to GHG emissions, constructed a Kupang IO Table for 2010, estimated potential pollutant sectors, increased the final demands in the leading sectors and investigated how these impacts are related in the sectors. We also estimated the amount of indirect GHG emission coefficient for every sector and the total amount of GHG emissions caused by economic activities indicated in the Kupang IO Table. In Indonesia, this is the first study to construct and calculate GHG emissions based on an IO table at the regional level. Our analysis showed approximately 0.09% to 0.1% of total GHG emissions in Indonesia by 2020 was emitted by economic activity in Kupang in 2010. As a proposal to the government, we designed a current and future framework to provide an optimal solution to integrate related sectors, natural resources, final demands and outline the feasibility of introducing renewable energy technology including energy supplies from a waste treatment plant.