Title
The biosentinel bioanalytical microsystem: Characterizing DNA radiation damage in living organisms beyond earth orbit
Date Issued
01 January 2016
Access level
open access
Resource Type
conference paper
Author(s)
Ricco A.J.
Hanel R.
Bhattacharya S.
Boone T.
Tan M.
Mousavi A.
Padgen M.
Gentry D.
Rademacher A.
Schooley A.
Klamm B.
Benton J.
Friedericks C.
Defouw G.
Parra M.
Marina D.
Lewis B.
Sanchez H.
Chartres J.
McIntosh D.
Lusby T.
Gavalas S.
Wheeler S.
NASA Ames Research Center
Publisher(s)
Transducer Research Foundation
Abstract
We report details and initial lab test results from an integrated bioanalytical microsystem designed to conduct the first biology experiments beyond low Earth orbit (LEO) since Apollo 17 (1972). The 14-kg, 12 x 24 x 37-cm3 BioSentinel spacecraft will assay radiation-responsive yeast in its science payload by measuring DNA double-strand breaks (DSBs) repaired via homologous recombination, a mechanism common to all eukaryotes including humans. S. cerevisiae (brewer’s yeast) in 288 microwells are provided with nutrient and optically assayed for growth and metabolism via 3-color absorptimetry periodically during the ~ 12-month-long spaceflight mission. BioSentinel, one of several secondary payloads to be deployed by NASA’s Space Launch System (SLS) as it carries Exploration Mission 1 into space in 2018, will receive commands and telemeter data to Earth from tens of millions of km.
Start page
352
End page
355
Language
English
OCDE Knowledge area
Biofísica
Otros temas de Biología
Scopus EID
2-s2.0-85030664382
Resource of which it is part
2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016
ISBN of the container
9781940470023
Conference
2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016
Sponsor(s)
Directly studying biology’s response to the interplanetary space radiation environment has never been attempted apart from a few costly, human-operated beyond-LEO missions. Robust, autonomous bioanalytical microsystems compatible with small satellites are poised to change this paradigm. BioSentinel is supported by NASA’s Advanced Exploration Systems division.
Sources of information:
Directorio de Producción Científica
Scopus