AIMS: To present the experience of creation, development and results of a nursing curriculum that integrates clinical simulation and patient safety with its challenges and achievements after four generations of graduates. EXPERIENCE DESCRIPTION: The School of Nursing at the Finis Terrae University is the result of a direct request from the authorities of the institution at a time when the country required an increase in the supply of nursing professionals. It started with a project that in the course of its development and implementation require several adjustments in programmatic terms. From its beginning, the project takes into consideration the integration of simulation and sets security at the heart of development. For this, we worked on new instruments that established how to implement the educational process, generating a model of teaching based on simulation, together with the establishment of control points that allowed the application of the model of continuous improvement. Through its development, seals are configured that differentiate the nursing student in the national environment. We are currently working to comply with international standards, periodically reviewing the implemented strategies and the way we teach for the benefit of our students. We consider as challenges the generation of interprofessional work, the strengthening of the teaching staff, and the generation of research, that demonstrate the benefits of having a curriculum for security based on simulation considering our local reality. CONCLUSIONS: The integration of simulation and patient safety in the nursing career curriculum is a challenge that requires the implementation of innovative processes, mobilizing resources of all kinds to achieve the goal. Strengthening leadership, clinical judgment and quality of nursing professionals deserve this kind of change. We believe changes like this in nursing education will enable us to achieve better health outcomes worldwide.