Title
Preclinical testing of Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom
Date Issued
01 November 2012
Access level
open access
Resource Type
journal article
Author(s)
Schneider F.S.
Starling M.C.
Duarte C.G.
Machado de Avila R.
Kalapothakis E.
Silva Suarez W.
Flores Garrido K.
Bonilla C.
Universidade Federal de Minas Gerais
Abstract
Bothrops andianus is a venomous snake found in the area of Machu Picchu (Peru). Its venom is not included in the antigenic pool used for production of the Peruvian anti-bothropic anti-venom. B. andianus venom can elicit many biological effects such as hemorrhage, hemolysis, proteolytic activity and lethality. The Peruvian anti-bothropic anti-venom displays consistent cross-reactivity with B. andianus venom, by ELISA and Western Blotting and is also effective in neutralizing the venom's toxic activities. © 2012 Elsevier Ltd.
Start page
1018
End page
1021
Volume
60
Issue
6
Language
English
OCDE Knowledge area
Toxicología
Subjects
Scopus EID
2-s2.0-84864810767
PubMed ID
Source
Toxicon
ISSN of the container
18793150
Sponsor(s)
This research was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil – CAPES (TOXINOLOGIA No 23038000825/2011-63 ), Fundação de Amparo a Pesquisa do Estado de Minas Gerais, Brazil (FAPEMIG) and by funds of the INCTTOX PROGRAM of Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (CNPq). The authors gratefully acknowledge the financial support and assistance of the Instituto Nacional de Salud (Lima, Peru) without which it would not have been possible to carry out this study. We would like to express our gratitude to Dr. Michael Richardson and Jessica McCormack for revising this manuscript.
Instituto Nacional de Ciência e Tecnologia em Toxinas - INCTTOX
Instituto Nacional De Salud Pública - INSP
Sources of information:
Directorio de Producción Científica
Scopus