The high pre-existing competition in the clothing industry increasingly demands greater efforts from companies; which, wanting to improve their processes, neglect operational aspects, generating low efficiency in production. Therefore, authors have shown that Lean Manufacturing and work standardization tools are effective in various industries in this regard. However, its benefits are rarely sustained. For this reason, the proposal described in this article is based on the integration of the standardization of processes with Autonomous Maintenance applying the 5S tool in an integral way, ensuring its sustainability over time, reducing the variability of the process flow and thus, achieve an increase in productive efficiency. The main result expected from the simulation is an increase in efficiency and a reduction in machine breakdowns. Summarizing, the integration of these three tools not only improves production efficiency in a company in the clothing sector, but also improves the work environment and the satisfaction of both: staff and customers.