This paper presents a study on the techno-economic efficiency of seismic strengthening techniques for old residential buildings, with application to construction typologies in Lisbon (stone masonry and “Placa” buildings). A comprehensive review on strengthening techniques and implications for the seismic behavior is made. Different strengthening schemes are implicitly simulated within equivalent frame models of the representative buildings. Then, pushover analysis is applied in order to compare the seismic performance of the buildings, before and after strengthening. A cost-benefit analysis of the strengthening solutions is finally performed, comparing the economic benefit gained by reducing the seismic damage, against the intervention cost.