This paper reports results from an investigation program launched with the objective of assessing fatigue lives of actual pipeline specimens with dents. Nine pipeline 3m-length specimens were constructed with low carbon steel pipes API 5L Gr. B. The specimens had 323mm diameter and 6.35mm wall thickness. The specimens were loaded with hydrostatic internal pressure pulsating at a 1Hz rate. Six specimens had 15% deep longitudinal smooth dents (ratio between dent depth and outside specimen diameter) and three specimens had complex longitudinal 6% deep dent shapes. Nominal and hot spot stresses and strains were determined by experimental techniques (Fiber Optic Bragg Strain Gages - FBSG, and Digital Image Correlation - DIC) and by a numerical technique (Finite Elements - FE). The stresses and strain fields determined from nominal loading conditions or from experimental measurements and from the finite element analyses were combined with different fatigue assessment methods. The estimated lives were compared with the actual test results. The fatigue assessment methods encompassed those proposed by the Pipeline Defect Assessment Manual (PDAM) and by the API 579-1/ASME FFS-1 Level 2 methods described in parts 12 (Dents) and 14 (Fatigue). Most of the predicted lives exhibited high level of conservatism. A Level 3 method that employed experimentally and numerically determined hot-spot strains in conjunction with a fatigue strain-life equation proposed by Coffin-Manson predicted fatigue lives very close to the test results.