Title
Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa
Date Issued
01 April 2000
Access level
metadata only access
Resource Type
journal article
Author(s)
Rodríguez G.
Estévez-Braun A.
Ravelo A.G.
Estévez-Reyes R.
González A.G.
Fdez-Puente J.L.
García-Grávalos D.
Universidad de la Laguna
Abstract
Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.
Start page
759
End page
762
Volume
10
Issue
8
Language
English
OCDE Knowledge area
Ciencias de las plantas, Botánica
Bioquímica, Biología molecular
Scopus EID
2-s2.0-0242689810
PubMed ID
Source
Bioorganic and Medicinal Chemistry Letters
ISSN of the container
0960894X
Sponsor(s)
This work has been partly funded by the Spanish DGES (projects PB 96-1033 and PB 96-10339, by the Gobierno Autónomo de Canarias, and by the Instituto Tecnológico de Canarias. H. Chávez thanks the Agencia Española de Cooperación Internacional for a MUTIS grant. Thanks are also due to Professor L. Ruı́z for gathering the plant.
Sources of information:
Directorio de Producción Científica
Scopus