This paper describes the procedure for controlling a non-linear process of Continuous Stirred Tank heater with Adaptive PID control and NEPSAC control. In particular, the interest is centered on analysis strategies to calculate a mathematical model, that later will be designed in the simulink software. The values shown in the analysis were selected from a CSTH with jacket implemented at the facilities of the University of Piura. This kind of control can be especially useful for non-linear process how this and also can be used to control other process. The implementation of the controllers was done using MATLAB Software and real parameters obtained from a biodigester prototype.