In this study, the mathematical form of the second order perturbed singular delay differential system is presented. The comprehensive features using the singular-point, perturbed factor and pantograph term are provided together with the shape factor of the second order perturbed singular delay differential system. The novel model is simulated numerically through the artificial neural networks (ANNs) based on the global/local optimization procedures, i.e., genetic algorithm (GA) and sequential quadratic programming (SQP). An activation function is constructed by using the differential model based on the second order perturbed singular delay differential system. The optimization of fitness function is performed through the hybrid computing strength of the ANNs-GA-SQP to solve the second order perturbed singular delay differential system. The exactness, substantiation, and authentication of the novel system is observed to solve three different variants of the novel model. The convergence, robustness, correctness, and stability of the numerical approach is performed using the comparison procedures of the available exact solutions. For the reliability, the statistical performances with necessary processes are provided using the ANNs-GA-SQP.