Title
Evidence for supercoughers in an analysis of six tuberculosis cohorts from China, Peru, the Gambia and Uganda
Date Issued
01 December 2019
Access level
metadata only access
Resource Type
journal article
Author(s)
Handel A.
Martinez L.
Sekandi J.N.
Bellan S.E.
Zhu L.
Chen C.
Liu Q.
Donkor S.
Sutherland J.
Hill P.C.
Grandjean L.
Whalen C.C.
Publisher(s)
International Union against Tubercul. and Lung Dis.
Abstract
BACKGROUND: It is very difficult to observe tuberculosis (TB) transmission chains and thus, identify superspreaders. We investigate cough duration as a proxy measure of transmission to assess the presence of potential TB superspreaders. DESIGN: We analyzed six studies from China, Peru, The Gambia and Uganda, and determined the distribution of cough duration and compared it with several theoretical distributions. To determine factors associated with cough duration, we used linear regression and boosted regression trees to examine the predictive power of patient, clinical and environmental characteristics. RESULTS: We found within-study heterogeneity in cough duration and strong similarities across studies. Approximately 20% of patients contributed 50% of total cough days, and around 50% of patients contributed 80% of total cough days. The cough duration distribution suggested an initially increasing, and subsequently, decreasing hazard of diagnosis. While some of the exposure variables showed statistically significant associations with cough duration, none of them had a strong effect. Multivariate analyses of different model types did not produce a model that had good predictive power. CONCLUSION: We found consistent evidence for the presence of supercoughers, but no characteristics predictive of such individuals.
Start page
1286
End page
1292
Volume
23
Issue
12
Language
English
OCDE Knowledge area
Sistema respiratorio
Scopus EID
2-s2.0-85077316021
PubMed ID
Source
International Journal of Tuberculosis and Lung Disease
ISSN of the container
10273719
Sponsor(s)
1Department of Epidemiology and Biostatistics, and Health Informatics Institute and Center for the Ecology of Infectious Diseases, University of Georgia, Athens, GA, USA; 2Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, People’s Republic of China; 3Vaccines and Immunity, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia; 4Centre for International Health, School of Medicine, University of Otago, Dunedin, New Zealand; 5Universidad Peruana Cayetano Heredia, Lima, Peru; 6Johns Hopkins Bloomberg School of Public Health, Department of International Health, Baltimore, MD, USA; 7Wellcome Centre for Clinical Tropical Medicine, Imperial College London, London, 8Institute of Child Health, University College London, London, UK;
Sources of information: Directorio de Producción Científica Scopus