Diverse tectonic regimes and the onset of Andean shortening are chronicled in principally nonmarine clastic deposits of Triassic through Paleogene age in the Eastern Cordillera, Subandean Zone, and Santiago-Marañón foreland basin of northern Peru. Detrital zircon U-Pb geochronological results for 16 sedimentary rock samples from a ~5km thick stratigraphic succession provide a framework to establish new depositional age constraints, infer sediment provenance, and reconstruct sediment routing systems through time. Integration of these results with U-Pb ages from metasedimentary basement samples, additional provenance data, facies distributions, and structural constraints support reconstructions of basin evolution involving: (1) Middle Triassic-Jurassic extension and post-rift thermal subsidence; (2) Late Jurassic-earliest Cretaceous unconformity development; (3) Early Cretaceous renewed regional subsidence; (4) latest Cretaceous shortening-induced flexural subsidence; and (5) Paleogene growth and advance of an integrated flexural foreland basin system.