Title
Heavy-tailed longitudinal regression models for censored data: a robust parametric approach
Date Issued
01 September 2019
Access level
metadata only access
Resource Type
journal article
Author(s)
Pontificia Universidad Católica de Chile
Publisher(s)
Springer New York LLC
Abstract
Longitudinal HIV-1 RNA viral load measures are often subject to censoring due to upper and lower detection limits depending on the quantification assays. A complication arises when these continuous measures present a heavy-tailed behavior because inference can be seriously affected by the misspecification of their parametric distribution. For such data structures, we propose a robust nonlinear censored regression model based on the scale mixtures of normal distributions. By taking into account the autocorrelation existing among irregularly observed measures, a damped exponential correlation structure is considered. A stochastic approximation of the EM algorithm is developed to obtain the maximum likelihood estimates of the model parameters. The main advantage of this new procedure os to allow estimating the parameters of interest and evaluating the log-likelihood function easily and quickly. Furthermore, the standard errors of the fixed effects and predictions of unobservable values of the response can be obtained as a byproduct. The practical utility of the proposed method is exemplified using both simulated and real data.
Start page
844
End page
878
Volume
28
Issue
3
Language
English
OCDE Knowledge area
Estadísticas, Probabilidad
Subjects
Scopus EID
2-s2.0-85073086111
Source
Test
ISSN of the container
11330686
Sponsor(s)
We are grateful to two anonymous referees and the associate editor for very useful comments and suggestions, which greatly improved this paper. We also acknowledge the support from FAPESP-Brazil (Grants 2011/22063-9, 2015/05385-3, 2014/ 02938-9 and 2018/05013-7), CNPq-Brazil (Grant 305054/2011-2), Grant FONDECYT 1170258 from the Chilean government and the Ministry of Science and Technology of Taiwan (Grant MOST105-2118-M-005-003-MY2).
Sources of information:
Directorio de Producción Científica
Scopus