Title
Extending multivariate Student's-t semiparametric mixed models for longitudinal data with censored responses and heavy tails
Date Issued
30 August 2022
Access level
metadata only access
Resource Type
journal article
Author(s)
Pontificia Universidad Católica de Chile
Publisher(s)
John Wiley and Sons Ltd
Abstract
This article extends the semiparametric mixed model for longitudinal censored data with Gaussian errors by considering the Student's (Formula presented.) -distribution. This model allows us to consider a flexible, functional dependence of an outcome variable over the covariates using nonparametric regression. Moreover, the proposed model takes into account the correlation between observations by using random effects. Penalized likelihood equations are applied to derive the maximum likelihood estimates that appear to be robust against outlying observations with respect to the Mahalanobis distance. We estimate nonparametric functions using smoothing splines under an EM-type algorithm framework. Finally, the proposed approach's performance is evaluated through extensive simulation studies and an application to two datasets from acquired immunodeficiency syndrome clinical trials.
Start page
3696
End page
3719
Volume
41
Issue
19
Language
English
OCDE Knowledge area
Bioinformática
Estadísticas, Probabilidad
Subjects
DOI
Scopus EID
2-s2.0-85130250441
PubMed ID
Source
Statistics in Medicine
ISSN of the container
02776715
Sponsor(s)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Grant/Award Number: 001; Fondo Nacional de Desarrollo Científico y Tecnológico, Grant/Award Number: 1170258; Fundação de Amparo à Pesquisa do Estado de São Paulo, Grant/Award Number: 2020/16713‐0; Millennium Science Initiative Program, Grant/Award Number: NCN17_059 Funding information
We thank the associate editor and two anonymous referees for their important comments and suggestions which lead to an improvement of this article. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ‐ Brazil (CAPES) ‐ Finance Code 001. L. M. Castro acknowledges support from Grant FONDECYT 1220799 and Millennium Science Initiative Program ‐ NCN17_059 from the Chilean government. Larissa A. Matos acknowledges support from FAPESP‐Brazil (Grant 2020/16713‐0).
Sources of information:
Directorio de Producción Científica
Scopus